EASY
Diploma
IMPORTANT
Earn 100

"In the field of observation, chance favours the prepared mind"- Louis Pasteur. Using the discovery of penicillin as an example, discuss the influence of an open-minded attitude on our perceptions.

Important Questions on Medicinal Chemistry

EASY
Diploma
IMPORTANT
Hydrochloric acid is primarily responsible for the acidity of gastric juice. Calculate the concentration, in mol dm-3 and mass percentage of hydrochloric acid in the sample of gastric juice with pH 1.5 and density 1.03 kg dm-3.
EASY
Diploma
IMPORTANT

A well-known brand of antacids contains 0.160 g of aluminium hydroxide and 0.105 g of magnesium carbonate in each tablet.

Determine which of the two components of the tablet will neutralise the most acid?

EASY
Diploma
IMPORTANT
Two substances commonly used in antacid tablets are magnesium hydroxide and aluminium hydroxide. Suggest why compounds such as sodium hydroxide or potassium hydroxide cannot be used as antacids?
EASY
Diploma
IMPORTANT
An acetate buffer was prepared from 500 cm3 of 0.100 mol dm-3 ethanoic acid (pKa=4.76) and 16.4 g of solid sodium acetate. Assuming that the addition of sodium acetate does not affect the solution volume, calculate the pH of this buffer solution.
EASY
Diploma
IMPORTANT
State the pH range in which acetate buffers can be used.
MEDIUM
Diploma
IMPORTANT
An acetate buffer was prepared from 500 cm3 of 0.100 mol dm-3 ethanoic acid (pKa=4.76) and 16.4 g of solid sodium acetate. Deduce the molecular and ionic equations that show the buffer action of this solution when a small amount of hydrochloric acid is added and when a small amount of sodium hydroxide is added.
EASY
Diploma
IMPORTANT
Phosphoric acid (pKa1=2.12, pKa2=7.20, pKa3=12.3) and its ions can produce several acid-base buffer systems that exist at different pH. Identify the conjugate acid and the conjugate base in the buffer solution with pH=6.8 prepared from phosphoric acid and sodium hydroxide. 
EASY
Diploma
IMPORTANT
Phosphoric acid (pKa1=2.12, pKa2=7.20, pKa3=12.3) and its ions can produce several acid-base buffer systems that exist at different pH. Calculate the mole ratio of the conjugate acid (H2PO4-) and conjugate base (HPO42-) at pH 6.8 in the solution.