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In the given pedigree, circles represent females and squares represent males. Filled shapes indicate affected individuals for a particular trait, while unfilled shapes indicate unaffected individuals. Carrier status is not shown in the pedigree. Study the following statements about this pedigree and choose the correct option(s).

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Statement 1- Trait follows X-linked recessive mode of inheritance.
Statement 2- Trait follows X-linked dominant mode of inheritance.
Statement 3- Trait follows autosomal recessive mode of inheritance.
Statement 4- Individual II-1 is a carrier for the trait.
Statement 5- Individual III- 4 is a carrier for the trait.
Statement 6- Individual I-1 is a carrier for the trait.

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Important Questions on Principles of Inheritance and Variation

HARD
In the following human pedigree, the filled symbols represents the affected individuals. Identify the type of given pedigree.


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EASY
Which one of the following symbols represents mating between relatives in human pedigree analysis?
HARD
A colourblind man marries a woman with normal sight who has no history of colour blindness in her family. What is the probability of their sons being colourblind?
MEDIUM

The following two pedigrees describe the autosomal genetic disorders P and Q in Family 1 and Family 2, respectively.

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Choose the CORRECT statement from the following options.

HARD
Pick out the correct statements:
(i) Haemophilia is a sex-linked recessive disease.
(ii) Down's syndrome is due to aneuploidy.
(iii) Phenylketonuria is an autosomal recessive gene disorder.
(iv) Sickle cell anaemia is an X-linked recessive gene disorder.
MEDIUM

From the following, find out the symbol used in the human pedigree analysis representing males.

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People suffering from albinism cannot synthesize:
HARD

The following question has four choices. Choose the best option.

In the given pedigree chart, the trait shown is :

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MEDIUM
An abnormal human baby with 'XXX' sex chromosomes was born due to:
EASY
Assertion (A): Pedigree analysis helps to work out the possible genotypes from the knowledge of the respective phenotypes.
Reason (R): Pedigree is a chart showing record of inheritance of certain traits over two or more ancestral generations of a person.
MEDIUM
If a colour-blind man marries a woman who is homozygous for normal colour vision, the probability of their son being colour-blind is
EASY
Which of the following most appropriately describes haemophilia?
HARD
Match the human disorders shown in Group I with the biochemical processes in Group II. Choose the correct combination.
 
Group I Group II
P. Phenylketonuria i. Melanin synthesis
Q. Albinism ii. Conversion of Phenylalanine to Tyrosine
R. Homocystinuria iii. Tyrosine degradation
S. Argininemia iv. Methionine metabolism
  v. Urea Synthesis
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A woman heterozygous for colour blindness marries a colour-blind man. What would be the ratios of carrier daughters, colour-blind daughters, normal sons, and colour-blind sons in the F1 generation?

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Children suffering from phenylketonuria are given food low in phenylalanine and supplemented with tyrosine. This is because they
MEDIUM

The diagram below represents the pedigree of a certain genetic disease (affected individuals are shaded). What is the mode of inheritance of the gene responsible for this disease?

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EASY
In the following symbols, used in human pedigree analysis, identify the symbol that denotes consanguineous mating.